The Role Of Fundamental Research And Biotechnology

Resistance to antibiotics is becoming a major problem worldwide. exacerbating this situation is
the fact that few new antibiotics be in the development pipeline, and, indeed, no novel class of
antibiotics has been introduced into medical praxis in more than 20 years. It is proposed that the
solutions to the problem of antibiotic impedance will be found only finished cardinal research
that will probably use bioengineering as a tool. A variety of novel approaches being utilized in
university laboratories and biotechnology companies are outlined. 2 approaches in particular,
namely, Synsorbs and recombinant cationic peptide antimicrobials, that have been developed
through the Canadian Bacterial Diseases Network, a national research consortium, are discussed.
One of the major problems with respect to antibiotic chemotherapy
is that, despite the intensifier research that is being
conducted by the multibillion-dollar pharmaceutical industry,
no novel chemic class of antibiotics has been discovered in
the past 20 years [1]. Indeed, whole recently introduced antibiotic
compounds are permutations (i.e., improved versions) of preexisting
compounds.



Thus, a situation whereby bacterium can mutate
known resistance mechanisms to combat these improved
relatives of earlier antibiotics has been created, and it is not
queer for significant resistance to be observed hitherto before
design of such antibiotics into the clinic [2]. One global
priority must therefore be to encourage the development of
novel antimicrobials, which will result in diversification of the
weapons available in the war against pathogenic bacteria.
Two of the major limitations of this objective are the high
cost (â€"$300 one thousand thousand per new chemical entity) of drug development
within pharmaceutical companies and the observation
that more of the larger multinational companies have actually
decreased their activities or even ceased to invest in the discovery
of new antibiotics [3]. Does...If you want to get a full essay, order it on our website: Orderessay



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